He was a prominent figure in movements like Alchimia and Memphis. He has designed furniture for the most known Italian and European companies. For Olivetti he has been Director of Design from 1988 to 2002. He realized architectural projects all over the globe including residential, industrial, corporate and cultural buildings. For various Italian and foreign banks he has designed working environments and corporate image; has designed exhibition systems for many museums in Europe.
In 2000 he was appointed Officer of Italian Republic by President Ciampi. In 2001 he has been nominated Professor at the IUAV in Venice. In 2006 he received the Honorary Doctorate from Kingston University. In 2008 he has been nominated Professor at the Design Faculty of the Politecnico of Milan and Member of the Accademia Nazionale di San Luca in Rome. During 2018 Michele De Lucchi is editor in chief of the new “Domus” magazine.